Akt Inhibitor XIX, 3CAI 3-Chloroacetyl-indole, 2-Chloro-1-(1H-indol-3-yl)ethanone A cell-permeable chloroacetyl-indole compound that inhibits Akt1 and Akt2 kinase activity (IC50 <1 µM) by directly targeting Akt PH domain, exhibiting little or much reduced activity against a panel of 84 other kinases. Effectively inhibits Akt-mediated downstream effector proteins phosphorylation in a time-dependent manner, resulting in effective apoptosis induction in HCT116 and HT29 cultures (by 55% and 60%, respectively; 4 µM for 4 days). Reported to retard HCT116-derived tumor growth in mice (EC50 = 30 mg/kg; 5 times/wk for 3 wks via p.o.) in vivo. 产品信息 Form Pink solid Molar mass 193.6 Protect from Light 是的 Protect from Moisture 是的 Packaged under inert gas 是的 Purity ≥98% by HPLC Solubility DMSO Chemical formula C10H8ClNO CAS number 28755-03-5 商店和运输信息 Storage -20°C Ship Dry Ice Only Standard Handling
