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3-Deazaneplanocin A
A lysine methyltransferase EZH2 (KMT63) inhibitor
Product Overview
Product Name: 3-Deazaneplanocin A
Alternate Name/Synonyms: DZNep; NSC 617989; 5R-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1S,2R-diol
Description: A lysine methyltransferase EZH2 (KMT63) inhibitor. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.
Peptide Sequence: N/A
Appearance: Off-white solid
Formulation: N/A
CAS Number: 102052-95-9
Molecular Formula: C₁₂H₁₄N₄O₃
Molecular Weight: 262.26
Purity: ≥98%
Solubility:DMSO (20 mg/ml) or EtOH (1 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: C1=CN=C(C2=C1N(C=N2)C3C=C(C(C3O)O)CO)N
InChi: InChI=1S/C12H14N4O3/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14)/t8-,10-,11+/m1/s1
InChi Key: OMKHWTRUYNAGFG-IEBDPFPHSA-N
PubChem CID: 73087
MDL Number: MFCD12545899
USAGE: For Research Use Only! Not For Use in Humans. |