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Leukadherin-1
A small molecule agonist of integrin CD11b/CD18
Product Overview
Product Name: Leukadherin-1
Alternate Name/Synonyms: 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid; LA1
Description: A novel small molecule agonist of integrin CD11b/CD18 (also known as Mac-1). LA1 increases the extent of CD11b/CD18-dependent cell adhesion of transfected cells and of primary human and mouse neutrophils, which results in decreased chemotaxis and transendothelial migration. LA1 also decreases leukocyte recruitment and reduced arterial narrowing after injury in rats. In addition, compared to a known integrin antagonist IMB-10, LA1 better preserves kidney function in a mouse model of experimental nephritis.
Peptide Sequence: N/A
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 344897-95-6
Molecular Formula: C₂₂H₁₅NO₄S₂
Molecular Weight: 421.49
Purity: ≥97% by HPLC
Solubility:DMSO (10 mM)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: C1=CC=C(C=C1)CN2C(=O)C(=CC3=CC=C(O3)C4=CC=C(C=C4)C(=O)O)SC2=S
InChi: InChI=1S/C22H15NO4S2/c24-20-19(29-22(28)23(20)13-14-4-2-1-3-5-14)12-17-10-11-18(27-17)15-6-8-16(9-7-15)21(25)26/h1-12H,13H2,(H,25,26)/b19-12-
InChi Key: AEZGRQSLKVNPCI-UNOMPAQXSA-N
PubChem CID: 5342077
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans. |