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Sphingosine Kinase Inhibitor, SKI-II
A non-lipid pan-sphingosine kinase (SK) inhibitor
Product Overview
Product Name: Sphingosine Kinase Inhibitor, SKI-II
Alternate Name/Synonyms: 4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
Description: Cell-permeable. SKI-II is selective a non-lipid sphingosine kinase (SK) inhibitor. It displays non-ATP-competitive inhibition of human recombinant GST-SK 1 with an IC50 value of 0.5 µM, with no inhibition against ERK2, PI3-kinase, or PKCα at concentrations up to 60 µM.
Peptide Sequence: N/A
Appearance: Off-white solid
Formulation: N/A
CAS Number: 312636-16-1
Molecular Formula: C₁₅H₁₁ClN₂OS
Molecular Weight: 302.78
Purity: ≥90% by NMR
Solubility:DMSO (100 mM)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl
InChi: InChI=1S/C15H11ClN2OS/c16-11-3-1-10(2-4-11)14-9-20-15(18-14)17-12-5-7-13(19)8-6-12/h1-9,19H,(H,17,18)
InChi Key: ZFGXZJKLOFCECI-UHFFFAOYSA-N
PubChem CID: 753704
MDL Number: MFCD00733553
USAGE: For Research Use Only! Not For Use in Humans. |