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RO-3306
A selective CDK 1 inhibitor
Product Overview
Product Name: RO-3306
Alternate Name/Synonyms: (5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one
Description: Cell-permeable. A selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Arrests cell cycle at G1, S, and G2/M and induces apoptosis in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines, and suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387.
Peptide Sequence: N/A
Appearance: Brown solid
Formulation: N/A
CAS Number: 872573-93-8
Molecular Formula: C₁₈H₁₃N₃OS₂
Molecular Weight: 351.45
Purity: ≥95% by NMR
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: C1=CC2=C(C=CC(=C2)C=C3C(=O)N=C(S3)NCC4=CC=CS4)N=C1
InChi: InChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10+
InChi Key: XOLMRFUGOINFDQ-MHWRWJLKSA-N
PubChem CID: 44450571
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans. |