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NSC-687852
A potent ubiquitin C-terminal hydrolase 5 (UCHL5) inhibitor
Product Overview
Product Name: NSC-687852
Alternate Name/Synonyms: 3,5-bis[(4-nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one; (3E,5E)-3,5-bis[(4-nitrophenyl)methylene]-1-prop-2-enoyl-piperidin-4-one; b-AP15
Description: Cell-permeable. Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. NSC-687852 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.
Peptide Sequence: N/A
Appearance: Pale yellow solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₂H₁₇N₃O₆
Molecular Weight: 419.39
Purity: ≥98% by HPLC
Solubility:DMSO (35 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: C=CC(=O)N1CC(=CC2=CC=C(C=C2)[N+](=O)[O])C(=O)C(=CC3=CC=C(C=C3)[N+](=O)[O-])C1
InChi: InChI=1S/C22H17N3O6/c1-2-21(26)23-13-17(11-15-3-7-19(8-4-15)24(28)29)22(27)18(14-23)12-16-5-9-20(10-6-16)25(30)31/h2-12H,1,13-14H2/b17-11+,18-12+
InChi Key: GFARQYQBWJLZMW-JYFOCSDGSA-N
PubChem CID: 5351435
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans. |