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Triptolide
A NF-kappaB inhibitor
Product Overview
Product Name: Triptolide
Alternate Name/Synonyms: TPL
Description: Triptolide, a diterpenoid triepoxyde, a purified component of a traditional Chinese medicine, inhibits transcriptional activation of NF- κB and downregulates the expression of various NF- κB-regulated genes. Displays Immunosuppressive, anti-inflammatory, anti-angiogenic and antitumor activity. A combination of TRAIL and triptolide enhance apoptosis in cholangiocarcinoma cell lines.
Peptide Sequence: N/A
Appearance: Off-white solid
Formulation: N/A
CAS Number: 38748-32-2
Molecular Formula: C₂₀H₂₄O₆
Molecular Weight: 360.4
Purity: ≥97% by HPLC
Solubility:DMSO (20 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CC(C)C12C(O1)C3C4(O3)C5(CCC6=C(C5CC7C4(C2O)O7)COC6=O)C
InChi: InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
InChi Key: DFBIRQPKNDILPW-CIVMWXNOSA-N
PubChem CID: 107985
MDL Number: MFCD00210565
USAGE: For Research Use Only! Not For Use in Humans. |