BML-286 Cell-permeable compound that disrupts Wnt signaling by binding to the PDZ domain of dishevelled (Kd=10.6 µM). Blocked Wnt3a-induced transcription activity and was able to supress the Wnt pathway-dependent growth of prostate cancer PC-3 cells (IC50=12.5 µM). BML-286 was also capable of supressing Wnt signaling in vivo (Xenopus embryo and mouse hyaloids vessel system). Product Specification Alternative Name: 3289-8625 Formula: C22H18N2O4 MW: 374.4 CAS: 294891-81-9 Purity: ≥98% (TLC) Appearance: Off-white solid. Solubility: Soluble in DMSO (10mg/ml). Long Term Storage: -20°C
