FH535 Antagonizes Wnt/β-catenin/Tcf-mediated transcription as well as PPARγ and δ activity. Able to inhibit the recruitment of the co-activators β-catenin and GRIP1, both of which are activators for both pathways. FH535 was toxic (LC50=5 to 15µM) to 10 of 12 carcinoma cell lines tested. A unique tool to study the relationship between Wnt and PPAR signaling pathways. Product Specification Alternative Name: N-(2-Methyl-4-nitrophenyl)-2,5-dichlorobenzenesulfonamide Formula: C13H10Cl2N2O4S MW: 361.2 CAS: 108409-83-2 Purity: ≥98% (TLC) Appearance: Yellow solid. Solubility: Soluble in DMSO (20mg/ml). Long Term Storage: -20°C
