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SB203580
p38/RK MAP Kinase Inhibitor
SB203580 is a pyridinyl imidazole inhibitor widely used to elucidate the roles of p38 mitogen-activated protein (MAP) kinase [1].
SB203580 inhibits also the phosphorylation and activation of protein kinase B (PKB, also known as Akt) [2]. Both kinases are involved in a wide array of signaling pathways, including the TLR signaling pathway [3].
Moreover, several studies suggest that p38 MAPKs regulate distinct phases of autophagy. p38 can elicit autophagy via Beclin1. Contrarily, p38α has also been reported to inhibit autophagy by interfering with the trafficking of Atg9.
Working concentration: 1-20 μM
Purity: >99% (HPLC, TLC)
Solubility: DMSO (50 mg/ml)
Synonym: 4-(4’-Fluorophenyl)-2-(4’-methylsulfinylphenyl)-5- (4’-pyridyl)-imidazole
Molecular weight: 377.44
Formula: C6H16FN3OS
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