Loxoribine Loxoribine is a guanosine analog derivatized at position N7 and C8. This nucleoside is a very powerful stimulator of the immune system but until recently the mechanisms responsible for this immunostimulatory activity was unknown [1]. It appears that similarly to imiquimod, a small synthetic antiviral molecule, loxoribine activates the innate immune system through Toll-like receptor 7 and that this activation requires endosomal maturation2. Loxoribine recognition is restricted to TLR7. Specificity: human/mouse TLR7 agonist Working concentration: 1 mM (300 µg/ml° Endotoxin level: EndoFit™ (<0.001 EU/μg) Solubility: 100 mM in DMSO