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L18-MDP
Muramyl dipeptide (MDP) is the minimal bioactive peptidoglycan motif common to all bacteria, the essential structure required for adjuvant activity in vaccines. MDP has been shown to be recognized by NOD2, but not TLR2, nor TLR2/1 or TLR2/6 associations [1,2]. In an attempt to enhance the protective activity against bacterial infection, numerous derivatives of MDP have been synthesized. Among them, L18-MDP, a 6-O-acyl derivative with a stearoyl fatty acid, showed the highest activity [3]. In HEK-Blue™ NOD2 cells, L18-MDP was 10 times more efficient than MDP to induce NF-κB activation.
Specificity: NOD2 agonist
Working concentration: 1 - 100 ng/ml
Endotoxin level: <0.125 EU/mg
Solubility: 1 mg/ml in water
Formula: C37H66N4O12
Molecular weight: 758.94
Synonym: 6-O-stearoyl-N-Acetyl-muramyl-L-alanyl-D-isoglutamine |