|
Leptomycin B
Nuclear export inhibitor
Leptomycin B, an inhibitor of nuclear export, can be used to study nucleo-cytoplasmic translocation. It has been demonstrated that Leptomycin B can cause the nuclear accumulation of proteins that shuttle between the cytosol and nucleus such as IRAK-1and NLRC5 [1, 2]. The cellular target of Leptomycin B has been identified as CRM1 (exportin 1), an evolutionarily conserved receptor for the nuclear export signal of proteins [3].
Working concentration: 50-200 nM
Endotoxin Levels:<0.001 EU/µg
Appearance: Clear, colorless solution
CAS number: 87081-35-4
Molecular weight: 540.73
Formula: C33H48O6 |