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Cyclosporin A
Calcineurin inhibitor
Cyclopsporin A is a calcineurin inhibitor that exerts its immunosuppressive effects through the down-regulation of NFAT (nuclear factor of activated T cells) transcription factor, thus preventing the transcription of T cell effector cytokines [1]. Moreover, NFAT has been implicated in the downstream signaling of Dectin-1 which is important in the innate immune response against fungal infection [2]. Conversely, it has been demonstrated that inhibition of calcineurin in macrophages enhances NF-κB activation [3] and can trigger TLR signaling by activating both the MyD88-dependent and the MyD88-independent pathways [4].
Working concentration: 50 nM - 1.5 μM
CAS number: 59865-13-3
Endotoxin levels: <0.001 EU/µg
Solubility: DMSO (50 mg/ml)
Molecular weight: 1202.61 |