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Biotin-Geldanamycin
Labeled geldanamycin analog
Biotin-GA was generated by biotinylation of geldanamycin at the C17 position. This labeled GA retains its activity against Hsp90 and therefore can be used to identify novel Hsp90 inhibitors through a time-resolved fluorescence resonance energy transfer-based HTS assay which measures the binding of biotin-GA to the N-terminal ATP-binding domain of Hsp90.
Working concentration: 1 nM - 10 μM
Formula: C56H88N8O12S
Molecular weight: 1097
Solubility: Soluble in DMSO, ethanol, methanol (10 mg/ml)
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