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Anti-KCNQ1 Potassium Channel, clone N31A/10
Species Reactivity Key Applications Host Format Antibody Type
R, H IHC Mouse Purified Monoclonal Antibody
Description:
Anti-KCNQ1 Potassium Channel Antibody, clone N31A/10
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Molecular Weight:
75 kDa calculated
Immunogen:
Recombinant protein corresponding to human KCNQ1.
Clone:
N31A/10
Isotype:
IgG1κ
Background Information:
KCNQ1 is a member of the K+ channel gene family that when mutated can cause hearing loss. The family is defined by transmembrane domains, single pore-loop K+ channel alpha subunits. KCNQ1 may have an important part in the repolarization of the cardiac action potential in the inner ear, as well as potassium homeostasis. KCNQ1 has been found to be responsible for over 50% of inherited long QT syndrome.
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Species Reactivity:
Rat
Human
Species Reactivity Note:
Demonstrated to react with rat. Predicted to react with human based on immunogen design.
Control:
Rat brain tissue
Quality Assurance:
Evaluated by Immunohistochemistry in rat brain tissue.
Immunohistochemistry Analysis: 1:400 dilution of this antibody detected KCNQ1 in rat brain tissue. May have a tendency to stain vascular tissue.
Purification Method:
Protein G
Presentation:
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
P51787
Entrez Gene Number:
NP_000209
Gene Symbol:
KCNQ1
ATFB3
KVLQT1
ATFB1
KCNA8
Kv1.9
KCNA9
LQT
JLNS1
WRS
Kv7.1
RWS
SQT2
LQT1
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Alternate Names:
potassium voltage-gated channel, KQT-like subfamily, member 1
Voltage-gated potassium channel subunit Kv7.1
KQT-like 1
potassium voltage-gated channel subfamily KQT member 1
IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
kidney and cardiac voltage dependend K+ channel
slow delayed rectifier channel subunit
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
This gene encodes a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome and familial atrial fibrillation. The gene is located in a region of chromosome 11 that contains a number of contiguous genes, which are abnormally imprinted in cancer and the Beckwith-Wiedemann syndrome. This gene is also imprinted, with preferential expression from the maternal allele in some tissues, excluding cardiac muscle. Alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq].
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Key Applications:
Immunohistochemistry
UniProt Summary:
FUNCTION: Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to f |