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Anti-Chloride intracellular channel protein (CLIC1), clone CPTC-CLIC1-1
Species Reactivity Key Applications Host Format Antibody Type
H WB, IHC Mouse Purified Monoclonal Antibody
Description:
Anti-Chloride intracellular channel protein (CLIC1) Antibody, clone CPTC-CLIC1-1
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Molecular Weight:
~27 kDa observed
Immunogen:
Full length recombinant protein corresponding to human CLIC1.
Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program.
Clone:
CPTC-CLIC1
Isotype:
IgG2aκ
Background Information:
Chloride intracellular channel protein 1 (CLIC1) is a part of the CLIC family of proteins. This family of proteins reconstitute in phospholipid vesicles and have been shown to have chloride channel action. CLIC1 may rotate between membrane-bound and soluble forms since it has been seen as a membrane protein and in the cytoplasm. When there is a lack of detergent, CLIC1 becomes membrane-bound and can act as an anion-selective channel. Recently, it has been shown that CLIC1 is required in angiogenesis and has a part in controlling integrin cell surface expression.
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Species Reactivity:
Human
Species Reactivity Note:
Demonstrated to react with human.
Application Notes:
Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH. (http://antibodies.cancer.gov/antibodies/detail/CPTC-CLIC1-2)
Control:
Human liver tissue lysate
Quality Assurance:
Evaluated by Western Blot in human liver tissue lysate.
Western Blot Analysis: 0.25 µg/mL of this antibody detected CLIC1 on 10 µg of human liver tissue lysate.
Purification Method:
Protein G
Presentation:
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
O00299
Entrez Gene Number:
NP_001279
Gene Symbol:
CLIC1
G6
NCC27
p64CLCP
hRNCC
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Alternate Names:
chloride intracellular channel 1
Chloride channel ABP
RNCC protein
Nuclear chloride ion channel 27
nuclear chloride ion channel protein
Regulatory nuclear chloride ion channel protein
chloride intracellular channel protein 1
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Immunohistochemistry
Entrez Gene Summary:
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq].
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UniProt Summary:
FUNCTION: Can insert into membranes and form chloride ion channels. Channel activity depends |