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Anti-KCNQ4 Potassium Channel, clone N43/6
Species Reactivity Key Applications Host Format Antibody Type
R, H IHC, WB Mouse Purified Monoclonal Antibody
Description:
Anti-KCNQ4 Potassium Channel Antibody, clone N43/6
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Specificity:
This antibody recognizes KCNQ4 potassium channel at ~77 kDa. In some lysates, an uncharacterized band may be observed at ~25 kDA.
Molecular Weight:
~77 kDa observed
Immunogen:
Recombinant protein corresponding to human KCNQ4.
Clone:
N43/6
Isotype:
IgG1λ
Background Information:
KCNQ4 is a member of the K+ channel gene family that when mutated can cause hearing loss. The KCNQ family of channels have been shown to only reside in the nuclei of the central auditory pathway. KCNQ4 could be responsible for neuronal excitability in outer hair cells and type 1 hair cells. KCNQ4 is not found in any other region of the brain.
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Species Reactivity:
Rat
Human
Species Reactivity Note:
Demonstrated to react with rat. Predicted to react with human based on immunogen design.
Application Notes:
Immunohistochemistry Analysis: 1:400 dilution from a previous lot detected KCNQ4 in rat brain tissue.
Control:
Rat brain membrane tissue lysate
Quality Assurance:
Evaluated by Western Blot in rat brain membrane tissue lysate.
Western Blot Analysis: 2 µg/mL of this antibody detected KCNQ4 on 10 µg of rat brain membrane tissue lysate.
Purification Method:
Protein G
Presentation:
Purified mouse monoclonal IgG1λ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
P56696
Entrez Gene Number:
NP_004691
Gene Symbol:
KCNQ4
Kv7.4
KV7.4
KQT-like 4
DFNA2
DFNA2A
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Alternate Names:
potassium voltage-gated channel, KQT-like subfamily, member 4
Potassium channel subunit alpha KvLQT4
potassium channel KQT-like 4
Voltage-gated potassium channel subunit Kv7.4
potassium voltage-gated channel subfamily KQT member 4
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunohistochemistry
Western Blotting
Entrez Gene Summary:
The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
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UniProt Summary:
FUNCTION: Probably important in the regulation of neuronal excitability. May underlie a potass |