英文名:Dactinomycin, Actinomycin D, ACTD 中文名: 更生霉素, 放线菌素D CAS: 50-76-0 说明:放线菌素D(Dactinomycin D)又称更生霉素,分子中含有一个苯氧环结构,通过它连接两个等位的环状肽链。此肽链可与DNA分子的脱氧鸟嘌呤发挥特异性相互作用,使dactinomycin D嵌入DNA双螺旋的小沟中,与DNA形成复合体,阻碍RNA多聚酶的功能,抑制RNA的合成,特别是mRNA的合成。属于周期非特异性药物。一次静脉注射给药后,很快从血浆消除,多数药物以原形经胆汁和尿液排出。抗瘤谱较窄,用于肾母细胞瘤、绒毛膜上皮癌、横纹肌肉瘤和神经母细胞瘤等。 Sigma相关产品资料: Sigma A1410 Actinomycin D from Streptomyces sp., ~98% (HPLC) Synonym: Actinomycin C1, Actinomycin IV, Dactinomycin CAS Number: 50-76-0 Linear Formula: C62H86N12O16 Molecular Weight: 1255.42 Beilstein Registry Number: 605235 EC Number: 200-063-6 MDL number: MFCD00005033 PubChem Substance ID: 24890541 Description Biochem/physiol Actions An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes. Caution Hygroscopic and light sensitive. 性质 biological source from Streptomyces sp. assay ~98% (HPLC) form powder color red, powder red to orange mp 251-253 solubility DMSO: 1 mg/mLethanol: soluble storage temp. 2-8°C |