产品说明 A cell-permeable dibenzazepine (dbz) compound that acts as a potent γ-secretase inhibitor and significantly lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model (100 µmol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC50 = 1.7 nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and ApcMin mouse models (10 µmol/kg, i.p). 产品信息 Form White solid Primary Target γ-secretase Secondary target Notch processing (IC50 = 1.7 nM in SupT1 cells) Protect from Light 是的 Packaged under inert gas 是的 Cell permeable 是的 Purity ≥95% by HPLC Chemical formula C26H23F2N3O3 CAS number 209984-56-5 Storage -20°C Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice Standard Handling