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产品说明
A cell-permeable isophthalamide compound containing hydroxyethylamine motif that binds to BACE-1 active site and potently blocks its proteolytic activity (IC50 = 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells). Displays greater selectivity over other aspartyl proteases (IC50 = 0.23 µM, 7.6 µM and >50 µM for BACE-2, cathepsin D, and renin, respectively).
产品信息
Form Off-white solid
Primary Target BACE-1 human
Primary Target IC50 15 nM
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥95% by HPLC
Chemical formula C31H38N4O5S
CAS number 797035-11-1
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |