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产品说明
A cell-permeable, active site directed, irreversible serine protease inhibitor that belongs to the class of isocoumarin analogs. Acts as a potent and selective inhibitor of γ-secretase and blocks the production of both amyloid-β40 (Aβ40) and Aβ42 (IC50 < 100 µM) in HEK293 cells expressing wild-type and Swedish-mutant β-amyloid precursor protein (APP). Note: t1/2 = 200 min in 100 µM HEPES, 500 µM NaCl, and 10% DMSO, pH 7.5.
产品信息
Form Yellow solid
Primary Target γ-secretase and blocks the production of both Aβ40 and Aβ42 in HEK293 cells expressing wild-type and Swedish-mutant β-amyloid precursor protein (APP)
Primary Target IC50 IC50 < 100 µM)
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥97% by HPLC
Chemical formula C10H8ClNO3
CAS number 62252-26-0
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |