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PP1 Analog II, 1NM-PP1
Mutant Kinases Inhibitor II, 4-Amino-1-tert-butyl-3-(1′-naphthylmethyl)pyrazolo[3,4-d]pyrimidine, NM
A cell-permeable and reversible PP1 analog (Cat. No. 529579) that acts as a potent and selective ATP-competitive inhibitor of mutant kinases over wild-type (IC50 = 3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µM for c-Fyn; 4.3 nM for I338G, v-src-as1 vs. 28 µM for v-src; 5 nM for F80G, CDK2-as1 vs. 29 µM for CDK2; 8 nM for F89G, CAMK IIα-as1 vs. 24 µM for CAMKII; 120 nM for T315A, c-Abl-as2 vs. 3.4 µM for c-Abl). Shown to activate mutants of Ire1, a transmembrane kinase. Also available as a 10 mM solution in DMSO (Cat. No. 529606).
产品信息
Form White solid
Primary Target T339G
Primary Target IC50 3.2 nM
Secondary target IC50 = c-Fyn-as1 vs. 1 µM for c-Fyn; 4.3 nM for I338G, v-src-as1 vs. 28 µM for v-src; 5 nM for F80G, CDK2-as1 vs. 29 µM for CDK2; 8 nM for F89G, CAMK IIa-as1 vs. 24 µM for CAMKII; 120 nM for T315A, c-Abl-as2 vs. 3.4 µM for c-Abl
Molar mass 331.4
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
ATP Competitive 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C20H21N5
CAS number 221244-14-0
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |