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PPM1D Phosphatase Inhibitor
2,5-bis-(2-Thienylidene)cyclopentanone, CCT007093, PP2Cδ Inhibitor I, Wip1 Inhibitor I
A cell-permeable thienylidene cyclopentanone compound that inhibits the PPM ser/thr phosphatase member PPM1D/PP2Cδ/WIP1 (IC50 = 8.4 µM), while exhibiting little activity against PPM1A even at concentrations as high as 100 µM. Selectively inhibits the growth of high PPM1D-expressing tumor cells (SF50 = 0.13, 0.17 & 0.48 µM for MCF-3B, KPL-1, & MCF-7, respectively, in colony formation assays), but not low PPM1D-expressing tumor cells (SF50 = 34 & >50 µM for 239T & HeLa, respectively). Inhibition of p38 MAP kinase activity by SB203580 (Cat. Nos. 559389, 559395, & 559398) is shown to fully prevent PPM1D inhibitor-induced growth arrest of MCF-7 cells.
产品信息
Form Yellow solid
Molar mass 272.4
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility DMSO
Chemical formula C15H12OS2
CAS number 1087-07-6
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |