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Pepstatin A, Penetratin
PepA-RQIKIWFQNRRMKWKK-OH, PepA-Antp43-58
A Pepstatin A (PepA; Cat. No. 516481) penetratin (pAntp43-58) conjugate (PepA-P) that is ~75% less potent against Cathespins D/E (IC50 = 920 nM) than PepA in cell-free assays, presumably due to its decreased solubility. However, with its enhanced permeability, PepA-P is much more active than PepA in inhibiting cellular aspartic protease activity in MCF7 (94.1% vs. 54.6% inhibition wtih 10 µM respective compound), Boleths, and Dendritic cultures. PepA-P, but not PepA, effectively interferes with antigen processing by primary APCs and the subsequent activation of antigen-specific memory T cells.
产品信息
Peptide Sequence PepA-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-CO2H
Form White lyophilized solid
Formulation Supplied as a trifluoroacetate salt.
Molar mass 2914.6
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility H2O
Chemical formula C138H229N39O28S
商店和运输信息
Storage -20°C
Ship Blue Ice Only
Standard Handling |