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MEK Inhibitor VII
SL327, Z-& E-α-(Amino-((4-aminophenyl)thio)methylene)-2-(trifluoromethyl)benzeneacetonitrile
A cell-permeable vinylogous cyanamide that acts as a selective inhibitor of MEK1/2 (IC50 = 180 nM and 220 nM, respectively). Shown to inhibit AP-1 activity (IC50 = 2.03 µM). Inhibits ERK1, MKK3/p38, MKK4, JNK, and PKC activities at higher concentrations (IC50 > 10 µM). Reported to offer neuroprotection against ischemic brain injury in mice by selectively blocking ERK1/2 activation. Also suppresses IL-1β expression. Displays enhanced aqueous solubility compared to U0126 (Cat. No. 662005). Uncompetitive with respect to ATP. Supplied as a mixture of Z- and E-isomers.
产品信息
Form Off-white solid
Primary Target MEK 1, MEK 2
Primary Target IC50 180 nM, 220 nM
Secondary target AP-1 activity (IC50 = 2.03 µM)
Molar mass 335.4
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥97% by HPLC
Solubility DMSO or EtOH
Chemical formula C16H12F3N3S
CAS number 305350-87-2
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |