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MEK Inhibitor II
2-Chloro-3-(N-succinimidyl)-1,4-naphthoquinone
A cell-permeable 1,4-naphthoquinone compound that acts as potent and selective inhibitor of MEK (IC50 = 0.38 µM for MEK1). It shows little effect on PKC and PKA, and inhibits Raf1 and ERK1 only at much higher concentrations (IC50 = 34.5 and 82.9 µM, respectively).
产品信息
Form Yellow solid
Primary Target MEK1
Primary Target IC50 0.38 µM
Secondary target Raf1 and ERK1 (IC50 = 34.5 and 82.9 µM, respectively)
Molar mass 289.7
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥97% by HPLC
Solubility DMSO
Chemical formula C14H8NO4Cl
CAS number 623163-52-0
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Carcinogenic / Teratogenic |