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产品信息
CAS number 544678-85-5
Storage +2°C to +8°C
Form Light yellow solid
Primary Target MMP-13 activity
Primary Target IC50 8 nM
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥98% by HPLC
Chemical formula C22H20F2N4O2
A pyrimidine dicarboxamide compound that potently inhibits MMP-13 activity (IC50 = 8 nM) with expected selectivity over MMP-1, -2, -3, -7, -8, -9, -10, -12, -14 and -16 as determined by conformational structure analysis. Shown to bind to the MMP-13 catalytic domain and act as a non-zinc-chelating inhibitor. |