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MMP/TACE Substrate, FS-6
The widely used MMP substrate FS-1 (Cat. No. 03-32-5032) is modified by an N-terminal lysine elongation to produce a broad-spectrum MMP and TACE substrate that displays improved water solubility and substrate sensitivities. Exhibits 2- to 9-fold higher specificity constant (kcat/Km) towards MMP-1, -8, -13, -14 when compared with FS-1 and ~2-fold higher kcat/Km towards TACE when compared with TACE Substrate II and III (Cat. Nos. 616402 and 616403, respectively). It has been used successfully in detecting T98G glioma cell surface-associated MMP activity and is shown to be resistant to proteolysis by human leukocyte elastase, trypsin, and ADAM-10.
产品信息
Peptide Sequence Mca-Lys-Pro-Leu-Gly~Leu-Dpa-Ala-Arg-NH2
Form Lyophilized
Formulation Supplied as a trifluoroacetate salt.
Molar mass 1221.3
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility H2O or 5% Acetic Acid
Chemical formula C55H80N16O16
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |