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Gö 6976
A cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC; IC50 = 7.9 nM for rat brain). Selectively inhibits Ca2+-dependent PKC α-isozyme (IC50 = 2.3 nM) and PKCβI (IC50 = 6.2 nM). Does not affect the kinase activity of the Ca2+-independent PKC δ-, ε-, and ζ-isozymes even at micromolar levels. Reported to inhibit PKCµ at higher concentrations (IC50 = 20 nM). A 500 µg/ml solution of Gö 6976 (Cat. No. 365253) in anhydrous DMSO is also available.
产品信息
Form Off-white solid
Primary Target PKC
Primary Target IC50 7.9 nM
Secondary target Ca2+-dependent PKC α-isozyme (IC50 = 2.3 nM) and PKCβI (IC50 = 6.2 nM) , PKCµ at higher concentrations IC50 = 20 nM
Molar mass 378.4
Protect from Light 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C24H18N4O
CAS number 136194-77-9
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |