Gö 6976 A cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC; IC50 = 7.9 nM for rat brain). Selectively inhibits Ca2+-dependent PKC α-isozyme (IC50 = 2.3 nM) and PKCβI (IC50 = 6.2 nM). Does not affect the kinase activity of the Ca2+-independent PKC δ-, ε-, and ζ-isozymes even at micromolar levels. Reported to inhibit PKCµ at higher concentrations (IC50 = 20 nM). A 500 µg/ml solution of Gö 6976 (Cat. No. 365253) in anhydrous DMSO is also available. 产品信息 Form Off-white solid Primary Target PKC Primary Target IC50 7.9 nM Secondary target Ca2+-dependent PKC α-isozyme (IC50 = 2.3 nM) and PKCβI (IC50 = 6.2 nM) , PKCµ at higher concentrations IC50 = 20 nM Molar mass 378.4 Protect from Light 是的 Purity ≥95% by HPLC Solubility DMSO Chemical formula C24H18N4O CAS number 136194-77-9 商店和运输信息 Storage +2°C to +8°C Ship Ambient Temperature Only Standard Handling
