EG5 INHIBITOR IV, VS-83

Eg5 Inhibitor IV, VS-83
5-Fluoro-3,4-dihydro-4(3′-hydroxyphenyl)quinazoline-2(1H)-thione
A cell-permeable Monastrol (Cat. No. 475879) analog with much enhanced potency and selectivity (over 8 other kinesins) in inhibiting mitotic kinesin Eg5-ATPase activity (IC50 = 1.17 vs. 20.73 µM for VS-83 and Monastrol, respectively) and in inducing monoasters formation (EC50 = 7.27 vs. 58.74 µM for BSC-1 cells treated with VS-83 and Monastrol, respectively). Shown to exhibit ≥10-fold antiproliferative activity than Monastrol against U-87 MG, U-118 MG, and U-373 MG glioblastoma cells.
产品信息
Form  White solid
Molar mass  274.3
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥99% by HPLC
Solubility  DMSO or EtOH
Chemical formula  C14H11FN2OS
CAS number  909250-29-9
商店和运输信息
Storage  -20°C
Ship  Ambient Temperature Only
Regulatory Review