|
Eg5 Inhibitor III, Dimethylenastron
7,7-Dimethyl-4-(3-hydroxyphenyl)-5-oxo-3,4,5,6,7,8-hexahydroquinazolin-2(1H)-thione
A cell-permeable quinazoline-thione compound that acts as a potent, specific, and reversible inhibitor of the microtubule-stimulated ATPase activity of the mitotic motor, Eg5 (IC50 = 200 nM). Exhibits little effect on the ATPase activity of kinesin-1, -4, -7 and -10 and is ~100-fold more potent than Monastrol (Cat. No. 475879). Also inhibits bipolar spindle formation in both HeLa cells and in Xenopus egg extracts and induces cell cycle arrest (~1 µM). Shown to induce mitotic arrest and apoptosis and upregulate Hsp70 in human multiple myeloma cells.
产品信息
Form Light yellow solid
Primary Target microtubule-stimulated ATPase activity of the mitotic motor
Primary Target IC50 200 nM
Molar mass 302.4
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
Reversible 是的
Purity ≥95% by HPLC
Solubility DMSO or MeOH
Chemical formula C16H18N2O2S
CAS number 863774-58-7
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Harmful |