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分子生化试剂 >> 生化试剂 |
CALPHOSTIN C, C. CLADOSPORIOIDES
产品编号: |
208725-50UG
查看说明书 |
产品名称:
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CALPHOSTIN C, C. CLADOSPORIOIDES .0 订购此产品 |
供应商:
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Merck |
规格: |
*** |
目录价: |
1,217.00 |
库存状态: |
3周到货 |
CAS编号:
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121263-19-2 |
应用范围: |
生化实验 |
种属来源: |
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相关信息: |
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Calphostin C, Cladosporium cladosporioides
A cell permeable, highly specific inhibitor of protein kinase C (IC50 = 50 nM) that interacts with the protein’s regulatory domain by competing at the binding site of diacylglycerol and phorbol esters. Does not compete with Ca2+ or phospholipids. At higher concentrations inhibits myosin light chain kinase (IC50 > 5 µM), protein kinase A (IC50 > 50 µM), protein kinase G (IC50 > 25 µM), and p60v-src (IC50 > 50 µM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Requires brief exposure to light for activation.
产品信息
Form Light brown lyophilized solid
Primary Target PKC
Primary Target IC50 50 nM
Secondary target mlck (IC50 = 5 µM), protein kinase A (IC50 > 50 µM), protein kinase G (IC50 > 25 µM), and p60v-src (IC50 > 50 µM)
Molar mass 790.8
Protect from Light 是的
Cell permeable 是的
Purity ≥95% by HPLC
Solubility DMSO or EtOH
Chemical formula C44H38O14
CAS number 121263-19-2
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |
保存条件: |
2°C - 8°C |
说明书地址: |
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