CALPHOSTIN C, C. CLADOSPORIOIDES

Calphostin C, Cladosporium cladosporioides
A cell permeable, highly specific inhibitor of protein kinase C (IC50 = 50 nM) that interacts with the protein’s regulatory domain by competing at the binding site of diacylglycerol and phorbol esters. Does not compete with Ca2+ or phospholipids. At higher concentrations inhibits myosin light chain kinase (IC50 > 5 µM), protein kinase A (IC50 > 50 µM), protein kinase G (IC50 > 25 µM), and p60v-src (IC50 > 50 µM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Requires brief exposure to light for activation.
产品信息
Form  Light brown lyophilized solid
Primary Target  PKC
Primary Target IC50  50 nM
Secondary target  mlck (IC50 = 5 µM), protein kinase A (IC50 > 50 µM), protein kinase G (IC50 > 25 µM), and p60v-src (IC50 > 50 µM)
Molar mass  790.8
Protect from Light  是的
Cell permeable  是的
Purity  ≥95% by HPLC
Solubility  DMSO or EtOH
Chemical formula  C44H38O14
CAS number  121263-19-2
商店和运输信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Standard Handling