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Complement C4b, Human
Native, human C4b complement component. Cleavage of the C4 α-chain at peptide bond 77 by activated C1 enzyme results in the production of C4a (M.W. 8,758) and C4b (M.W. 193,000) fragments. The C4b fragment is a glycoprotein composed of the modified C4 α-chain (α′) and intact β- and γ-chains. Like C3b, C4b has the transient ability to form a covalent ester bond with a variety of target cell surfaces. Once bound to the target surface, C4b becomes an essential non-enzymatic subunit of the classical pathway C3 cleaving enzyme (C4b,C2a). In addition, surface bound C4b has opsonic and immune adherence activities which are mediated via binding to the CR1 (CD35) complement receptor which is found on a variety of inflammatory cells.
产品信息
Form Liquid
Formulation In PBS, pH 7.2.
Preservative None
Molar mass 193000
Avoid freeze/thaw 是的
Purity ≥95% by SDS-PAGE
Contaminants IgG, IgA, IgM, Factor B, Factor H, C3, ceruloplasmin, or albumin: ≤trace amounts
Source Prepared from plasma of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
商店和运输信息
Storage ≤ -70°C
Ship Dry Ice Only
Standard Handling |