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Complement C8, Human
Native, human C8 complement component. Glycoprotein composed of three non-identical subunits of M.W. 64 kDa (α), 64 kDa (β), and 22 kDa (γ). Present in normal human serum at 55 µg/ml. On activation of complement via either the classical or alternative pathway, C5 is cleaved into C5a and C5b fragments. The nascent C5b fragment binds to C6, C7, and C8 resulting in formation of the C5b-8 complex on target surfaces. Each membrane-bound, hydrophobic C5b-8 complex combines with three to six C9 molecules to complete the assembly of the lytic C5b-9 complement membrane attack complex (MAC).
产品信息
Form Liquid
Formulation In PBS, pH 7.2.
Molar mass 150000
Avoid freeze/thaw 是的
Specific activity ≥150,000 C8H50 units/mg
Purity ≥85% by SDS-PAGE
Contaminants IgG, IgA, IgM, albumin, C3, C4, C7, C9: ≤trace amounts
Source Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
CAS number 80295-58-5
商店和运输信息
Storage ≤ -70°C
Ship Dry Ice Only
Standard Handling |