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JAK2 [pYpY1007/1008] Polyclonal Antibody, Rabbit
This rabbit anti-JAK2 [pYpY1007/1008] polyclonal antibody is specific to mouse JAK2 [pY1007/pY1008]. JAK2 [pYpY1007/1008] polyclonal antibody recognizes the expressed product of the JAK2 gene. Janus Kinase 2 (JAK2) is a 130 kDa tyrosine kinase involved in cytoplasmic signal transduction. Validated application for JAK2 [pYpY1007/1008] polyclonal antibody is Western blotting.
Applications: validated for Western blotting
Host species and isotype: rabbit IgG.
Reactivity: mouse JAK2 [pY1007/pY1008]
Product size: 10 blot pack size.
Janus Kinase 2 (JAK2) is a 130 kDa tyrosine kinase involved in cytoplasmic signal transduction. Ligand binding to a variety of cell surface receptors (e.g., cytokine, growth factor, GPCRs) leads to an association of those receptors with JAK proteins, which are then activated via phosphorylation on tyrosines 1007 and 1008 in the kinase activation loop. Activated JAK proteins phosphorylate and activate STAT (signal transducers and activators of transcription) proteins, which then dimerize and translocate to the nucleus. Once in the nucleus, STAT proteins bind to DNA and modify the transcription of various genes, which can lead to various responses such as cell proliferation, cell survival and differentiation.
Reactivity: Rat,
Human,
Mouse
Validated Application: Western Blot
Host: Rabbit
SubClass (Isotype): IgG
Clonality: Polyclonal
Target Gene: JAK2 [pYpY1007/1008]
Gene ID: 3717
Label or Dye: Unconjugated
Target Modification State: Phospho
Product Size: 10 blots
Research Category: Signal Transduction
Purity or Quality Grade: Azide Free
Shipping Condition: Approved for shipment on Wet or Dry Ice
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store in freezer (-5 to -30°C). |