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JAK1 [pYpY1022/1023] Polyclonal Antibody, Rabbit
This rabbit anti-JAK1 [pYpY1022/1023] polyclonal antibody is specific to human and mouse JAK1 [pYpY1022/1023] protein. Janus Kinase 1 (JAK1) is a 130 kDa tyrosine kinase involved in cytoplasmic signal transduction. Validated application for JAK1 [pYpY1022/1023] polyclonal antibody is Western blotting.
Applications: validated for Western blot
Host species and isotype: rabbit IgG
Reactivity: human and mouse JAK1 [pYpY1022/1023]
Product size: 10 blots pack size
Janus Kinase 1 (JAK1) is a 130 kDa tyrosine kinase involved in cytoplasmic signal transduction. Ligand binding to a variety of cell surface receptors (e.g., cytokine, growth factor, GPCRs) leads to an association of those receptors with JAK proteins, which are then activated via phosphorylation on tyrosines 1022 and 1023 in the kinase activation loop. Activated JAK proteins phosphorylate and activate STAT (signal transducers and activators of transcription) proteins, which then dimerize and translocate to the nucleus. Once in the nucleus, STAT proteins bind to DNA and modify the transcription of various genes, which can lead to various responses such as cell proliferation, cell survival and differentiation.
Reactivity: Human,
Mouse
Validated Application: Western Blot
Host: Rabbit
SubClass (Isotype): IgG
Clonality: Polyclonal
Target Gene: JAK1 [pYpY1022/1023]
Gene ID: 3716
Label or Dye: Unconjugated
Target Modification State: Phospho
Product Size: 10 blots
Research Category: Signal Transduction
Purity or Quality Grade: Azide Free
Shipping Condition: Approved for shipment on Wet or Dry Ice
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store in freezer (-5 to -30°C). |