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Amyloid Beta (Abeta) [1-42] Rabbit mAb (clone 20-1)
For improved reproducibility and sensitivity please try Aβ [1-42] ABfinity™ Recombinant Rabbit Monoclonal Antibody Catalog# 700254.
Rabbit (monoclonal) anti- Abeta 42 clone 20-1 is a rabbit monoclonal antibody, which reacts with human and Mouse Abeta 42, and is validated for IHC and ELISA.
Amyloid beta (A4) precursor protein (APP) is a 100-140 kDa transmembrane glycoprotein existing as several isoforms. The amino acid sequence of APP contains the amyloid domain Abeta (Aβ), which can be cleaved by a two-step proteolytic cleavage and release Aβ peptides of Aβ [1-40], Aβ [1-42], and Aβ [1-43] corresponding to residues 40, 42, and 43 respectively. The extracellular plaque deposition and accumulation of the released Aβ peptides (β -amyloid), and intracellular neurofibrillary tangles (NFTs) in the brain, are the characteristics of Alzeimer disesease (AD). Increased release of the ‘longer forms’ of Ab peptide, Ab42 or Ab43, which have a greater tendency to aggregate than Ab40, occurs in
Reactivity: Human,
Mouse
Validated Application: Immunohistochemistry,
ELISA
Host: Rabbit
SubClass (Isotype): IgG
Clonality: Monoclonal
Clone ID: 20-1
Antibody Fragment: Whole Antibody
Target Gene: Amyloid beta (Abeta) [1-42]
Gene ID: 322
Gene Symbol: APBB1
Accession Number: NP_000475
Label or Dye: Unconjugated
Purification: Pure
Concentration: 0.5 µg⁄µl
Form: Liquid
High Throughput Compatibility: High Throughput-Compatible
Product Size: 25 µg
Volume: 50 µl
Shipping Condition: Wet Ice
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store at 2-8°C for up to one month. Store at –20°C for long-term storage. Avoid repeated freezing and thawing. |