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MMP-2, also known as gelatinase A or 72 kDa type IV collagenase is a member of the matrix metalloproteinase (MMP) family, composed of at least 25 secreted and membrane-bound zinc-dependent endopeptidases.1 Although precise physiological activators of MMPs are unknown, a variety of Serine proteinases and other MMPs in the extracellular environment execute the initial propeptide cleavage events. Loss of negative growth regulation and high invasive potential are neoplastic traits often associated with abnormal expression of MMPs.1,2
MMP-2 plays an important role in processes mediating the degradation of the extracellular matrix (ECM), inflammation, tissue repair, bone elongation, embryo development, tumor invasion and metastasis. Besides a catalytic domain, MMP-2 and the closely related MMP-9 (gelatinase B, 92 kDa type IV collagenase) contain a hemopexin-like domain and - unique among the metalloproteinases- three in-tandem fibronectin type II (FII) modules which are inserted in their
Reactivity: Rat,
Human,
Mouse,
Chimpanzee,
Rabbit,
Rhesus Monkey
Validated Application: Immunoprecipitation,
Western Blot
Host: Mouse
Clonality: Monoclonal
Clone ID: 101
Target Gene: MMP2
Gene ID: 4313
Label or Dye: Unconjugated
Product Size: 100 µg
Protein Family: Proteases, Peptidases & Inhibitors
Shipping Condition: Wet Ice
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store in freezer (-5 to -30°C). |