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Estrogen Receptor Alpha Mouse anti-Human Monoclonal Antibody (clone H4624)
Estrogen receptor α (ERα, ER; NR3A1) is a member of steroid receptor family. The natural ligand for ER is the classical estrogenic compound 17β-estradiol. ERα is expressed in a wide variety of tissues including bones, uterus, bladder, ovary, prostate, testis, epididymis, kidney, breast, heart, vessel wall, pituitary gland and hypothalamus. ER has a variety of central physiological roles, including those involved in maintenance of the reproductive, cardiovascular, musculoskeletal and central nervous systems. ERα has been shown to form homodimers as well as heterodimers with ERβ. Both ERα and ERβ can give rise to numerous isoforms.
Isotype
Mouse IgG2a
Clone/PAD
H4624
Immunogen
Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human ERα (2-180 aa).
Specificity
This antibody specifically recognizes human ERα and cross reacts with rat ERα. This antibody does not recognize ERβ. Not yet tested in other species.
Reactivity: Human,
Rat
Validated Application: Immunohistochemistry,
ELISA,
Immunoprecipitation,
Western Blot
Host: Mouse
Clonality: Monoclonal
Clone ID: H4624
Target Gene: Estrogen Receptor Alpha
Gene ID: 13982
Label or Dye: Unconjugated
Product Size: 100 µg
Protein Family: GPCR (G-Protein Coupled Receptors)
Research Category: Signal Transduction
Shipping Condition: Wet Ice
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store in freezer (-5 to -30°C). |