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Histone Methyltransferase Assay Reagent Kit
Description:
Histone Methyltransferase Assay Reagent Kit
Trade Name:
Upstate (Millipore)
Qty/Pk:
1 kit
Product Overview:
Accessory reagent kit for the analysis of histone methyltransferase activity.
Applications:
Accessory reagent kit for the analysis of histone methyltransferase activity.
Key Applications:
Histone Methyltransferase Assay (HMT)
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
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UniProt Summary:
FUNCTION: SwissProt: P50135 # Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
SIZE: 292 amino acids; 33295 Da
SUBUNIT: Monomer.
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: SwissProt: P50135 ## Belongs to the methyltransferase superfamily. HNMT family.
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Brand Family:
Upstate
Gene Symbol:
HNMT
HMT
HNMT-S2
HNMT-S1
Product Name:
Histone Methyltransferase Assay Reagent Kit
Quality Assurance:
Routinely evaluated by methylating core histones with PRMT1, active (14-474).
Components:
5X HMTase Assay Buffer
Core histones
P81 Phosphocellulose Squares (Cat.# 20-134)
UniProt Number:
P50135
Packaging:
Kit capacity: 100 assays
Entrez Gene Number:
NM_001024074.1
NM_001024075.1
NM_006895.2 |