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Anti-VEGF, clone VG1
Recommended Replacement for: 05-1117 is a recommended replacement for MAB3734
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PRODUCT FAMILY INFORMATION
VEGF Antibodies & Proteins
Millipore’s VEGF antibodies demonstrates specificity against Vascular Endothelial Growth Factor or VEGF. See below for related products for VEGF, based on the expertise of Upstate & Chemicon.
Millipore’s Anti- VEGF antibody demonstrates specificity against VEGF. See below for data, references and related products for VEGF. All Millipore antibodies are based on the expertise of Upstate & Chemicon.
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Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB Mouse Ascites Monoclonal Antibody
Description:
Anti-VEGF Antibody, clone VG1
Replaces:
05-1117 is a recommended replacement for MAB3734
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Specificity:
Detects the 121, 165, and 189 amino acid isoforms of VEGF.
Molecular Weight:
Approx. 12-28 kDa
Immunogen:
Recombinant human VEGF 189aa isoform
Clone:
VG1
Isotype:
IgG1κ
Background Information:
VEGF (Vascular endothelial growth factor, VEGFA, VEGF-A), a dimeric ligand, is among the most potent angiogenic mitogens. VEGF is secreted by tumor cells and other cells exposed to hypoxia. VEGF is a highly specific mitogen for vascular endothelial cells. Seven VEGF isoforms (a, b, c, d, e, f, g) are generated as a result of alternative splicing from a single VEGF gene. The most commonly studied isoforms are VEGF121, VEGF165, and VEGF189 (f, d and b, respectively) All seven isoforms differ in their molecular mass and in biological properties such as their ability to bind to cell-surface heparan-sulfate proteoglycans. The expression of VEGF is potentiated and is secreted by tumor cells in response to hypoxia, by activated oncogenes, and by a variety of cytokines.
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Species Reactivity:
Human
Mouse
Rat
Control:
NIH/3T3 cell lysate
Quality Assurance:
Evaluated by Western Blot in NIH/3T3 cell lysate.
Western Blot Analysis: A 1:500 dilution of this antibody detected VEGF on 10 µg of NIH/3T3 cell lysate.
Purification Method:
Unpurified
Presentation:
Unpurified mouse monoclonal IgG1κ in ascites fluid containing no preservatives.
Storage Conditions:
Stable for 12 months at -20°C from date of receipt.
Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
UniProt Number:
P15692
Entrez Gene Number:
NP_033531.3
Gene Symbol:
MGC70609
VPF
VEGF-A
VEGF
MVCD1
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Alternate Names:
Vascular permeability factor
vascular endothelial growth factor
vascular endothelial growth factor A
vascular endothelial growth factor isoform VEGF165
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
This gene product is a member of the PDGF/VEGF growth factor family. It is a mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Altern |