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Anti-Insulin, clone MAB1
Recommended Replacement for: CBL71
Species Reactivity Key Applications Host Format Antibody Type
H IH(P) Mouse Affinity Purified Monoclonal Antibody
Description:
Anti-Insulin Antibody, clone1
Replaces:
CBL71
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Specificity:
This antibody recognizes an epitope including the amino acid B30.
Molecular Weight:
Approx. 12 kDa
Immunogen:
Biosynthetic human insulin
Clone:
MAB1
Isotype:
IgG1
Background Information:
Insulin is a polypeptide hormone that regulates carbohydrate metabolism. Apart from being the primary agent in carbohydrate homeostasis, it has effects on fat metabolism.
Species Reactivity:
Human
Species Reactivity Note:
Human
Control:
Human pancreas tissue.
Quality Assurance:
Evaluated by Immunohistochemistry in human pancreas tissue.
Immunohistochemistry Analysis: 1.25 µg/mL of this antibody detected insulin in human pancreas tissue.
Purification Method:
Affinity Purfied
Presentation:
The monoclonal is presented as 1mg in 1ml phosphate buffered saline containing 10mM sodium azide. We recommend that each laboratory determine an optimum working titre for use in its particular application.
Storage Conditions:
Store at 2-8°C and use within 1 year from date of receipt.
UniProt Number:
P01308
Entrez Gene Number:
P01308
Gene Symbol:
ILPR
IRDN
OTTHUMP00000011161
OTTHUMP00000011162
OTTHUMP00000196038
insulin
proinsulin
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunohistochemistry (Paraffin)
UniProt Summary:
FUNCTION: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
SUBUNIT STRUCTURE: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
SUBCELLULAR LOCATION: Secreted.
INVOLVEMENT IN DISEASE: Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].
PHARMACEUTICAL USE: Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53.
SEQUENCE SIMILARITIES: Belongs to the insulin family.
SEQUENCE CAUTION: The sequence AAA59179.1 differs from that shown. Reason: Erroneous gene model prediction.
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Product Name:
Anti-Insulin, clone MAB1
Concentration:
Please refer to the Certificate of Analysis for the lot-specific concentration.
Antibody Type:
Monoclonal Antibody
Qty/Pk:
1 mg
Format:
Affinity Purified
Host:
Mouse
Applications:
Anti-Insulin Antibody, clone1 is an antibody against Insulin for use in IH(P). |