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Anti-Insulin, clone CE9H9
Recommended Replacement for: MAB10218
Species Reactivity Key Applications Host Format Antibody Type
H, B, Rb, Po, Sh, Gp, Ch, F IH(P) Mouse Unpurified Monoclonal Antibody
Description:
Anti-Insulin Antibody, clone CE9H9
Replaces:
MAB10218
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Specificity:
The antibody binds to insulin from human, cow, pig and rabbit and to pro-insulin from cow and pig.
Molecular Weight:
~12 kDa.
Immunogen:
Zinc containing crystalline human insulin
Clone:
CE9H9
Isotype:
IgG1
Background Information:
Insulin is a polypeptide hormone that regulates carbohydrate metabolism. Apart from being the primary agent in carbohydrate homeostasis, it has effects on fat metabolism.
Species Reactivity:
Human
Bovine
Rabbit
Pig
Sheep
Guinea Pig
Chicken
Fish
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Species Reactivity Note:
Proven to react with human, bovine, pig, rabbit, sheep and guinea pig.
Control:
Human pancreas tissue.
Quality Assurance:
Evaluated by Immunohistochemistry in human pancreas tissue.
IHC Analysis: A 1.25 µg/mL dilution of this antibody detected insulin in human pancreas tissue.
Purification Method:
Unpurified ascites
Presentation:
Unpurified mouse monoclonal as liquid ascites fluid containing no preservatives.
Storage Conditions:
1 year at -20°C from date of receipt
UniProt Number:
P01308
Entrez Gene Number:
P01308
Gene Symbol:
ILPR
IRDN
OTTHUMP00000011161
OTTHUMP00000011162
OTTHUMP00000196038
insulin
proinsulin
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunohistochemistry (Paraffin)
UniProt Summary:
FUNCTION: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
SUBUNIT STRUCTURE: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
SUBCELLULAR LOCATION: Secreted.
INVOLVEMENT IN DISEASE: Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].
PHARMACEUTICAL USE: Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53.
SEQUENCE SIMILARITIES: Belongs to the insulin family.
SEQUENCE CAUTION: The sequence AAA59179.1 differs from that shown. Reason: Erroneous gene model prediction.
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Product Name:
Anti-Insulin, clone CE9H9
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 μL
Format:
Unpurified
Host:
Mouse
Applications:
Detect Insulin using this Anti-Insulin Antibody, clone CE9H9 validated for use in IH(P). |