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Anti-HDAC1 Antibody, clone 2E10
Recommended Replacement for: 05-614
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REFERENCES
A transcriptional repressor co-regulatory network governing androgen response in prostate cancers.
Kern Rei Chng,Cheng Wei Chang,Si Kee Tan,Chong Yang,Shu Zhen Hong,Noel Yan Wei Sng,Edwin Cheung (2012) The EMBO journal.31
A radiosensitizing effect of artesunate in glioblastoma cells is associated with a diminished expression of the inhibitor of apoptosis protein survivin.
Sebastian Reichert,Vera Reinboldt,Stephanie Hehlgans,Thomas Efferth,Claus Rödel,Franz Rödel (2012) Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.103
NO-dependent protective effect of VEGF against excitotoxicity on layer VI of the developing cerebral cortex.
Faiza El Ghazi,Arnaud Desfeux,Carole Brasse-Lagnel,Christian Roux,Celine Lesueur,Danielle Mazur,Isabelle Remy-Jouet,Vincent Richard,Sylvie Jégou,Vincent Laudenbach,Stephane Marret,Soumeya Bekri,Vincent Prevot,Bruno J Gonzalez (2012) Neurobiology of disease.45
Neural differentiation of P19 carcinoma cells and primary neurospheres: cell morphology, proliferation, viability, and functionality.
Priscilla D Negraes,Telma T Schwindt,Cleber A Trujillo,Henning Ulrich (2012) Current protocols in stem cell biology.Chapter 2
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Species Reactivity Key Applications Host Format Antibody Type
H, M IP, WB Mouse Culture Supernatant Monoclonal Antibody
Description:
Anti-HDAC1 Antibody, clone 2E10
Replaces:
05-614
Promotional Text:
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Trade Name:
Upstate (Millipore)
Specificity:
HDAC-1
Molecular Weight:
60kDa
Immunogen:
KLH-conjugated, synthetic peptide (C-EEKPEAKGVKEEVKLA) corresponding to amino acids 467-482 of mouse HDAC1. The immunizing sequence is identical in human.
Clone:
2E10
Isotype:
IgG1
Species Reactivity:
Human
Mouse
Quality Assurance:
Routinely evaluated by immunoblot on RIPA lysates from 3T3/A31 cells.
Presentation:
100μl of culture supernatant containing 0.05% sodium azide. Frozen at -20°C.
Storage Conditions:
2 years at -20°C from date of shipment.
UniProt Number:
Q13547
Entrez Gene Number:
NM_004964.2
Gene Symbol:
HDAC1
RPD3L1
GON-10
DKFZp686H12203
HD1
RPD3
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunoprecipitation
Western Blotting
Entrez Gene Summary:
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
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UniProt Summary:
FUNCTION: SwissProt: Q13547 # Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H |