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Anti-Interleukin 4 (IL-4), clone 11.B.11
Species Reactivity Key Applications Host Format Antibody Type
M FC, EA Rat Purified Monoclonal Antibody
Description:
Anti-Interleukin 4 (IL-4) Antibody, clone 11.B.11
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Specificity:
This antibody recognizes IL-4.
Molecular Weight:
~ 15 kDa
Epitope:
Unknown
Immunogen:
Recombinant protein corresponding to mouse IL-4.
Clone:
11B11
Isotype:
IgG1κ
Background Information:
Interleukin-4 (IL-4) is a cytokine that stimulates activated B-cell and T-cell proliferation and induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. These Th2 cells, in turn, also produce IL-4. IL-4 also acts as a key regulator in humoral and adaptive immunity and induces B-cell class switching to IgE, as well as up-regulating MHC class II production. Mutations in the IL-4 gene may lead to a susceptibility to ischemic stroke or cerebral infarction. Overproduction of IL-4 is associated with allergies.
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Species Reactivity:
Mouse
Species Reactivity Note:
Demonstrated to react with mouse.
Application Notes:
Functional Activity Assay: A previous lot was utilized by an independent laboratory to show increased resistance of mice to Listeria monocytogenes infection after administration of anti-interleukin 4 (IL-4), clone 11.B.11. (Haak-Frendscho, M., et al., 1992).
Control:
MiCK-2™ cells
Quality Assurance:
Evaluated by Flow Cytometry in MiCK-2™ cells.
Flow Cytometry Analysis: 10 µg of this antibody detected IL-4 in MiCK-2™ cells.
Purification Method:
Protein G purfied
Presentation:
Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
P07750
Entrez Gene Number:
NP_067258.1
Gene Symbol:
IL4
Binetrakin
Pitrakinra
BSF1
BSF-1
IL-4
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Alternate Names:
B cell growth factor 1
B-cell stimulatory factor 1
B_cell stimulatory factor 1
Lymphocyte stimulatory factor 1
interleukin 4
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Flow Cytometry
Enzyme Assay
UniProt Summary:
FUNCTION: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
SUBCELLULAR LOCATION: Secreted.
SEQUENCE SIMILARITIES: Belongs to the IL-4/IL-13 family.
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Product Name:
Anti-Interleukin 4 (IL-4), clone 11.B.11
Concentration:
Please refer to the Certificate of Analysis for the lot-specific concentration.
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 μg
Format:
Purified
Host:
Rat
Applications:
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