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Anti-phospho-KDR/Flk-1/VEGFR2 (Tyr1054) Antibody, clone D1W, rabbit monoclonal
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PRODUCT FAMILY INFORMATION
Endothelial Cell Markers
The thin layer of cells that lines the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.
Endothelial cells are the thin layer of cells that lines the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall. Endothelial cells in direct contact with blood are called vascular endothelial cells, whereas those in direct contact with lymph are known as lymphatic endothelial cells.
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Species Reactivity Key Applications Host Format Antibody Type
H, M WB Rabbit Culture Supernatant Monoclonal Antibody
Description:
Anti-phospho-KDR/Flk-1/VEGFR2 (Tyr1054) Antibody, clone D1W, rabbit monoclonal
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Trade Name:
Upstate (Millipore)
Specificity:
KDR/Flk-1/VEGFR2 phosphorylated on Tyrosine 1054.
Molecular Weight:
152 kDa.
Immunogen:
KLH-conjugated, synthetic peptide encompassing the phosphorylated tyrosine residue 1054 of human KDR/Flk-1/VEGFR2.
Modifications:
Phosphorylation
Clone:
D1W
Isotype:
IgG
Species Reactivity:
Human
Mouse
Species Reactivity Note:
Predicted to have broad species cross-reactivity based on sequence homology.
Application Notes:
Western Blot: 1:1000-1:4000 dilution for the detection of phospho-KDR/Flk-1/VEGFR2 in RIPA lysates from CSF stimulated porcine aortic endothelial (PAE) cells expressing a human CSF-R1/murine KDR chimeric receptor.
Quality Assurance:
Routinely evaluated by immunoblot in RIPA lysates from CSF stimulated porcine aortic endothelial (PAE) cells expressing a human CSF-R1/murine KDR chimeric receptor.
Presentation:
Cultured supernantant with 0.05% sodium azide
Storage Conditions:
2 years at -20°C from date of shipment.
UniProt Number:
P35968
Entrez Gene Number:
NP_002244.1
Gene Symbol:
KDR
VEGFR-2
VEGFR2
VEGFR
CD309
FLK1
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
UniProt Summary:
FUNCTION: SwissProt: P35968 # Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
SIZE: 1356 amino acids; 151527 Da
SUBUNIT: Interacts with SHB upon VEGF activation. Interacts with HIV-1 Tat.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P35968 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 7 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
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Brand Family:
Upstate
Product Name:
Anti-phospho-KDR/Flk-1/VEGFR2 |