|
Anti-LAP2α, clone 3A3 Antibody (04-640)
Close
REFERENCES
Evolution in quantum leaps: multiple combinatorial transfers of HPI and other genetic modules in Enterobacteriaceae.
Armand Paauw,Maurine A Leverstein-van Hall,Jan Verhoef,Ad C Fluit (2010) PloS one.5
Species Reactivity Key Applications Host Format Antibody Type
H WB, IF Mouse Purified Monoclonal Antibody
Description:
Anti-LAP2α Antibody, clone 3A3
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Specificity:
Human LAP2α. Does not cross react with mouse or rat LAP2α
Molecular Weight:
76 kDa
Immunogen:
KLH conjugated synthetic peptide to C terminus region of human LAPα. This antibody detects LAP2α regardless of a naturally occurring Arginine to Cysteine mutation at position 690.
Clone:
clone 3A3
Isotype:
IgG1κ
Background Information:
The inner membrane of the nuclear envelope is connected to the nuclear lamina. The main components of the nuclear lamina are Type V intermediate filaments called lamins and lamin binding proteins including lamin B receptor, emerin, MANI, LAP1 (3 isoforms), and LAP2 (several isoforms). The lamins are divided into two groups: the constitutively expressed lamin B and the developmentaly regulated lamin A.
The best characterized isoforms of lamin binding protein LAP2 are LAP2α and LAP2β. LAP2β is a type II membrane protein in the inner nuclear membrane that binds lamin B and is important to cell viability and controlling nuclear lamina growth. LAP2α has been characterized as a nucleoplasmic protein that interacts with A-type lamins to control gene expression, transcription, and chromatin organization. LAP2 has a unique COOH terminus from the other LAP2 isoforms. The COOH terminus of LAP2 binds Rb (Retinoblastoma) and is thought to play a role in cell cycle progression and differentiation.
View All »
Species Reactivity:
Human
Quality Assurance:
routinely evaluated by immunoblot on lysates from K563 cells
Presentation:
Purified mouse monoclonal IgG1κ in buffer containing PBS with 0.05% NaN3.
Storage Conditions:
Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
UniProt Number:
P42166
Entrez Gene Number:
NM_003276
Gene Symbol:
TMPO
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
Immunofluorescence
Brand Family:
Upstate
Product Name:
Anti-LAP2α, clone 3A3 Antibody (04-640)
Concentration:
Please refer to the Certificate of Analysis for the lot-specific concentration.
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 µg
Format:
Purified
Host:
Mouse
Applications:
Anti-LAP2α Antibody, clone 3A3 detects level of LAP2α & has been published & validated for use in WB & IF. |